Volume 1, Issue 21


Cover Image

Cover Figure:  Interaction of immune cells within the microenvironment of chronic lymphocytic leukemia (CLL).
See the article by Maharaj et al.

WASHINGTON, September 26,  2017 – Welcome to the “Advance Notice,”  newsletter which provides highlights from issues of Blood Advances, the open-access journal of the American Society of Hematology (ASH), that  are hand-picked by Blood Advances Editor-in-Chief Robert Negrin, MD.

The brain and acute leukemia, cytoplasmic (BAALC ), a gene, when overexpressed, has been associated with a poor prognosis in patients with acute myeloid leukemia (AML). To date, little is known about BAALC expression and its impact in patients with acute promyelocytic leukemia (APL). Lucena-Araujo and colleagues studied BAALC expression in 221 patients with newly diagnosed disease. They show that BAALC expression is significantly lower in APL than in other subsets of AML but that, when found, it is associated with an inferior prognosis in APL as well.

Hematopoiesis during development occurs in several anatomic locations from the yolk sac to the liver and ultimately in the bone marrow. The fetal liver is a major site of expansion of the hematopoietic stem cell pool. Brouard et al identify a unique microenvironment supportive of megakaryocytes in the developing liver, which many have important implications for the discovery of regulators of platelet production.

Psychomotor slowing has been recognized in children with sickle cell disease (SCD), but less is known about this condition in adults. Jorgensen et al, conducted a cross-sectional study to assess this problem in a cohort of adult patients with SCD seen in an outpatient clinic, finding differences according to a number of factors, including disease genotype.

The reversal of oral factor Xa inhibitors can be a significant clinical challenge in the setting of emergencies or major bleeding. Siegal and colleagues  describe the safety and pharmakinetics of the reversal agent andexanet alfa.

Large granular lymphocytic (LGL) leukemia can present with unexplained cytopenias and can be confused with myelodysplastic syndromes. In the Commentary by Morgan et al, it is proposed that STAT3 sequencing can help make a more accurate diagnosis in a significant percentage of LGL leukemia patients.


Featured Visual Abstract

Gene editing rescue of a novel MPL mutant associated with congenital amegakaryocytic thrombocytopenia

Cédric Cleyrat, Romain Girard, Eun H. Choi, Éric Jeziorski, Thierry Lavabre-Bertrand, Sylvie Hermouet, Serge Carillo and Bridget S. Wilson





Blood Advances is the open-access journal of the American Society of Hematology (ASH) (, the world’s largest professional society concerned with the causes and treatment of blood disorders.

ASH’s mission is to further the understanding, diagnosis, treatment, and prevention of disorders affecting blood, bone marrow, and the immunologic, hemostatic, and vascular systems by promoting research, clinical care, education, training, and advocacy in hematology.