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Volume 2, Issue 6

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Cover Image

Cover Figure: Laser-induced cremaster arteriole murine thrombi with murine platelets. Incorporated human platelets derived from infused megakaryocytes were grown in the presence of SU6656. See the article by Jarocha et al.

WASHINGTON, March 27,  2018 – Welcome to the “Advance Notice,”  newsletter which provides highlights from issues of Blood Advances, the open-access journal of the American Society of Hematology (ASH), that  are hand-picked by Blood Advances Editor-in-Chief Robert Negrin, MD.

The interaction of malignancies with their stromal environment has been an increasingly studied area of tumor biology. In a Stimulus Report, Wasik and colleagues evaluate the role of mutations in the interaction between sphingosine-1-phosphate, a sphingolipid that regulates migration of lymphocytes, and sphingosine-1-phosphate receptor-1 (S1PR1) in a large series of patients with mantle cell lymphoma.

Mutations in the MDS1 and EVI1 complex (MECOM) have resulted in a rare congenital amegakaryocytic thrombocytopenia. Germeshausen and colleagues carefully evaluated 12 such cases to characterize this interesting but rare syndrome.

Alternatives to collection of blood products are being considered to address the shortage of these critical components. Megakaryocytes grown in vitro hold promise for generating platelets to meet the increasing demands for platelet transfusions. Jarocha et al assessed the roles of different kinase inhibitors for their ability to enhance functional platelet yield after megakaryocyte infusion, with interesting and hopefully clinically relevant findings.

Immune reconstitution following allogeneic hematopoietic cell transplantation is of critical importance as delay can result in significant morbidity and mortality from opportunistic infections. In an elegant study, Hardy and colleagues explored the transcriptome of cytomegalovirus-reactive T cells in recipients with different immune reconstitution kinetics, revealing interesting and potentially clinically actionable differences that suggest a potential role for epigenetic-based therapies.

Human T-cell leukemia virus type 1 (HTLV-1)–related adult T-cell leukemia is endemic in certain parts of the world. Malpica and colleagues analyzed a large cohort of patients with HTLV-1–related adult T-cell leukemia in North America. Their article highlights important biological and clinical features of the disease, helping to guide therapy.

The role of positron-emission tomography–based imaging of mucosa-associated lymphoid tumors remains poorly understood. Qi et al show uptake of [18F]fluorodeoxyglucose to be highly predictive for the ultimate outcome, demonstrating the importance of this evaluation for prognosis.
 

Featured Visual Abstract

Biological impact of α genes, β haplotypes, and G6PD activity in sickle cell anemia at baseline and with hydroxyurea

Genetic markers in patients with sickle cell anemia may affect responsiveness to treatment. Bernaudin and colleagues assessed the impact of α genes, β haplotypes, and glucose-6-phosphate dehydrogenase (G6PD) activity at baseline and after treatment with hydroxyurea, with important clinical ramifications.

 

 

 

 

 

Blood Advances is the open-access journal of the American Society of Hematology (ASH) (www.hematology.org), the world’s largest professional society concerned with the causes and treatment of blood disorders.

ASH’s mission is to further the understanding, diagnosis, treatment, and prevention of disorders affecting blood, bone marrow, and the immunologic, hemostatic, and vascular systems by promoting research, clinical care, education, training, and advocacy in hematology.