Volume 1, Issue 5


Cover Image

Cover Figure: Genomic distribution of 51 clonal chromosomal mosaic events detected in blood DNA.
See the article by Reina-Castillón et al.

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WASHINGTON, January 24,  2017 – Welcome to the “Advance Notice,”  newsletter which provides highlights from issues of Blood Advances, the open-access journal of the American Society of Hematology (ASH), that  are hand-picked by Blood Advances Editor-in-Chief Robert Negrin, MD.

Iron deficiency is a common hematologic problem. In the developing world, solutions are generally difficult due to the expense of diagnosis and therapy. In a Blood Advances Talk Armstrong describes the Lucky Iron Fish, a small piece of iron shaped like a fish that can be used during cooking to deliver a therapeutic dose of iron via leaching and is widely applicable in the developing world. We hope you enjoy listening to this description of a clever, simple solution to a worldwide problem.

It has been recognized that individuals who harbor cytomegalovirus (CMV) infections are at greater risk for AIDS disease progression after infection with HIV-1. This paper by Cheung et al sheds light on the mechanism of this observation related to the upregulation of the HIV-1 receptors CXCR4 and CCR5 and the downregulation of a variety of HIV-1 restriction factors. This fascinating observation details the complex interaction between CMV and HIV-1.

Clearance of ADAMTS13 by macrophages contributes to the clearance from the circulation. The mechanism of clearance is revealed by Verbij et al who discovered a role for CD163, identifying this cell surface protein as a candidate receptor for ADAMTS13.

Patients with FLT3-mutated acute myeloid leukemia are known to have a poor prognosis. In a clinical trial reported through the Alliance for Clinical Trials in Oncology, sorafenib was added to standard induction chemotherapy with daunorubicin and cytarabine and continued for 12 months of maintenance therapy. The impressive 1-year overall survival rate of 62% is far superior to historical rates and sets the stage for increased investigation of this agent in this high-risk patient population

Featured Visual Abstract

The class I scavenger receptor CD163 promotes internalization of ADAMTS13 by macrophages

Fabian C. Verbij, Nicoletta Sorvillo, Paul H. P. Kaijen, Johana Hrdinova, Ivan Peyron, Rob Fijnheer, Anja ten Brinke, Alexander B. Meijer, Floris P. J. van Alphen, Timo K. van den Berg, Jonas J. H. Graversen, Soren K. Moestrup, Jan Voorberg





Blood Advances is the official open-access journal of the American Society of Hematology (ASH) (, the world’s largest professional society concerned with the causes and treatment of blood disorders.

ASH’s mission is to further the understanding, diagnosis, treatment, and prevention of disorders affecting blood, bone marrow, and the immunologic, hemostatic, and vascular systems by promoting research, clinical care, education, training, and advocacy in hematology.