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Preventing Postpartum Hemorrhage in von Willebrand Disease: the Treatment(s) Conundrum

Postpartum hemorrhage (PPH)—defined as the loss of 500 ml or more of blood after childbirth—is the leading cause of maternal mortality in the developing world. Optimal management of PPH is still unsettled, especially in women with underlying von Willebrand disease (VWD). Because various treatment options are available, physicians are left to contemplate how best to prevent PPH in women with VWD. In this Point-Counterpoint series, cases is made for antifibrinolytic therapy (the Point commentary) and blood volume–based von Willebrand factor dosing (the Counterpoint commentary) to prevent PPH in women who present with VWD.

Copyright © 2017 American Society for Hematology

Postpartum hemorrhage is the leading cause of maternal mortality in the developing world. Optimal management of PPH is still unsettled, especially in women with underlying von Willebrand disease.