Table 1.

Classification of MGRS entities based on presence and site of deposition of monoclonal proteins in renal structures

MGRS with monoclonal protein deposition in renal structures
Glomerular depositionTubulointerstitial depositionIntrarenal vascular deposition
Amyloidosis (AL/AH/AHL)LCPT with and without crystalsAmyloidosis
Monoclonal fibrillary glomerulopathyCSHCrystalglobulinemia
Immunotactoid glomerulopathyAmyloidosisMIDD
Cryoglobulinemic GN (types I and II)MIDDCryoglobulinemic GN (types I and II)
MPGN associated with monoclonal immunoglobulin
MN secondary to monoclonal immunoglobulin
MGRS without monoclonal protein deposition in renal structures
Glomerular involvementTubulointerstitial involvementIntrarenal vascular involvement
TMAPOEMS syndrome
POEMS syndrome
  • AH, heavy chain amyloidosis; AHL, heavy and light chain amyloidosis; AL, light chain amyloidosis; C3GN, C3 glomerulonephritis; CSH, crystal-storing histiocytosis; HCDD, heavy chain deposition disease; HLDD, heavy and light chain deposition disease; LCDD, light chain deposition disease; LCPT, light chain proximal tubulopathy; MN, membranous nephropathy; POEMS, polyneuropathy organomegaly endocrinopathy monoclonal gammopathy, and skin changes.

  • Adapted from Ciocchini et al5 with permission.