Table 4.

Summary of the reported end-organ manifestations in MGRS entities

MGRS subtypeOrgans affected/manifestationsReferences
AmyloidosisHeart, liver, autonomic nerves, skin, gastrointestinal tract, pulmonary62
MIDDLiver, heart, peripheral nerves, lung, skin (seen in 35% of cases)28,63-65
Cryoglobulinemic GNVasculitis, Raynaud’s phenomenon, purpura, livedo reticularis, arthralgia, peripheral neuropathy29,48,49
C3GSkin necrosis11
LCPT with FSOsteomalacia28
CrystalglobulinemiaSkin rash, polyarthralgia, neuropathy29,66
CSHFS, spleen, lymph nodes, macrophage activation, cornea, lungs, thyroid, parotid gland, synovium, liver, brain, skin, subcutaneous fat9,55
POEMS syndromeSensory motor polyneuropathy, organomegaly, endocrinopathy, skin61