Table 3.

Syndromic approach to the clinical presentation of MGRS

Clinical syndrome/presentationAssociated MGRS entities
NSAmyloidosis (glomerular), MIDD
Nephritic-nephrotic syndrome (proteinuria, hematuria, hypertension, low complement levels, and renal insufficiency)PGNMID, ITG, FG, C3G with monoclonal immunoglobulin, cryoglobulinemic GN
Acute renal failureTMA, MIDD, and crystalglobulinemia
Proteinuria/progressive renal insufficiencyLCPT (with/without FS), MIDD, amyloidosis (tubulointerstitial and vascular), CSH, TMA
  • Adapted from Sethi et al29 with permission.