Table 1.

Patient characteristics by DE status, DH status, or other

CharacteristicOther* (N = 171)DE (N = 33)DH (N = 7)P
Age
 Median (range), y62 (19-89)62 (35-84)65 (44-77)
 >60 y96 (56)19 (58)4 (57)1.000
Sex
 Male89 (52)11 (33)3 (43).128
Stage at diagnosis
 I97 (57)26 (79)3 (43).030
 II74 (43)7 (21)4 (57)
Poor performance status
 ECOG >124 (14)4 (12)0 (0).831
 LDH > ULN44 (31)10 (37)3 (50).418
 Extranodal sites–any91 (53)21 (64)3 (43).458
  >15 (3)0 (0)0 (0)
 Supradiaphragmatic103 (60)22 (67)3 (43).517
 Ki67, median (range)80 (15-100)82 (25-95)85 (40-90).337
 Bulk >7.5 cm33 (21)5 (18)4 (57).075
COO
 GCB99 (65)13 (39)4 (57).019
 Non-GCB53 (35)20 (61)3 (43)
Stage-modified IPI
 Low (0-1 point)71 (51)19 (73)3 (50).180
 Intermediate (2 points)41 (30)3 (12)1 (17)
 High (3-4 points)27 (19)4 (15)2 (33)
  • Unless otherwise noted, all data are n (%). Bold indicates statistically significant results.

  • ECOG, Eastern Cooperative Oncology Group; IPI, International Prognostic Index; LDH, lactate dehydrogenase; ULN, upper limit of normal.

  • * Sufficient IHC/FISH in 59 cases for full DH/DE assessment.

  • Excludes DH cases.