Table 3.

Linkage disequilibrium among FCGR2A*27W, FCGR2C*ORF, 2B.4, and FCGR3A*158V determines major observed haplotypes

FCGR2A-27WFCGR2C-ORF, rs759550223FCGR2C-ncORF, rs76277413FCGR2B-2B.4, rs148754834; rs34701572FCGR3A-158VHaplotype frequency
ControlsCases
QSTOPWTno 2B.4F0.63900.5580
QSTOPWTno 2B.4V0.18800.2060
QSTOPWT2B.4F0.03190.0150
QSTOPWT2B.4VNA2.2e-07
QORFWTno 2B.4F5.9e-100.0055
QORFsplice*no 2B.4V0.01030.0172
QORFWTno 2B.4V0.00360.0016
QORFWT2B.4F3.5e-09NA
QORFWT2B.4V0.01020.0174
WSTOPWTno 2B.4F0.00360.0015
WSTOPWTno 2B.4V0.00360.0102
WSTOPWT2B.4F0.00340.0056
WSTOPWT2B.4VNA0.0036
WORFWTno 2B.4FNA0.0042
WORFWTno 2B.4V0.03170.0544
WORFWT2B.4V0.07430.0997
  • Data shown for 146 control individuals and 145 patients with newly diagnosed ITP (TIKI) who showed no CNV in CNR1 or CNR2. Bold text indicates the most common haplotypes. Frequencies of haplotypes are derived from posterior probabilities using observed alleles using the haplo.stats package in R. 2B.4 promoter constitutes the observation of a A at position −120 and C at position −386. The 2B.4 haplotype is solely observed as a promoter polymorphism of FCGR2B and SNPs are only indicated for this variant.

  • NA, haplotype not observed.