Table 3.

AMG 232 pharmacokinetic parameters

Cycle 1, day 1Cycle 1, day 7
tmax, hCmax, ng/mLAUC24h, ng⋅h/mLtmax, hCmax, ng/mLAUC24h, ng⋅h/mLCL/F, L/hAUC24h AR
AMG 232 60 mg
 n44444444
 MeanNC6693310NC665544012.41.79
 SDNC226884NC21020805.040.984
AMG 232 60 mg + trametinib 2 mg
 n10109
 MeanNC5202850
 SDNC2111120
AMG 232 90 mg
 n44333333
 MeanNC17907140NC135012 5007.271.77
 SDNC7021100NC10916701.050.291
AMG 232 180 mg
 n55455554
 MeanNC9626540NC141017 10017.72.38
 SDNC4633790NC79111 90014.80.834
AMG 232 240 mg
 n33022220
 MeanNC1280NCNC211020 10013.4NC
 SDNC194NCNC*NC*NC*NC*NC
AMG 232 360 mg
 n1010888886
 MeanNC509027 900NC352034 70022.51.11
 SDNC232016 500NC247031 70020.40.728
  • AR, accumulation ratio (AUC24h cycle 1, day 1/AUC24h cycle 1, day 7); Cmin, minimum observed serum concentration; NC, not calculated; SD, standard deviation.

  • * Standard deviation is not reported when n ≤ 2.