Table 4.

Trametinib pharmacokinetic parameters

Cycle 1, day 1Cycle 2, day 1
tmax, hCmax, ng/mLAUC6h, ng⋅h/mLtmax, hCmax, ng/mLAUC6h, ng⋅h/mL
n101010663
MeanNC8.9327.7NC28.0120
SDNC3.3410.1NC9.8117.1