Table 2.

Knee arthrotomy, synovectomy, and excisional debridement of soft tissue to bone perioperative hemostasis regimen without emicizumab

TimeSingle doseInterval, h
3*4612
PreoperativerFVIIa 180 μg/kg
POD 0-13rFVIIa 90 μg/kg and APCC 5000 IU
Preoperative (CVC placement on POD 14)rFVIIa 180 μg/kg
POD 0-13rFVIIa 90 μg/kg and APCC 5000 IU
POD 14-27rFVIIa 90 μg/kg and APCC 5000 IU
POD 28-41rFVIIa 90 μg/kg and APCC 5000 IU
POD 42-55rFVIIa 90 μg/kg and APCC 5000 IU
  • CVC, central venous catheter.

  • * Interval describes duration between alternating rFVIIa and APCC therapy (ie, rFVIIa alternating with APCC every 3 hours).

  • On POD 14, CVC placement was necessary, so tapering regimen was restarted.

  • After POD 55, regular bypassing agent prophylaxis regimen was resumed.