Table 4.

Comparison of incidence of grades 3/4 nonhematological toxicities among randomized patients with and without DS

Induction DS/non-DS, %PConsolidation DS/non-DS, %PIM-1 DS/ non-DS, %PDI-1 DS/ non-DS, %PIM-2 DS/ non-DS, %PDI-2 DS/ non-DS, %PMaintenance DS/non-DS, %P
Cardiovascular2.7/5.0.651.3/1.2.882.7/0.6.0321.4/1.1.800/00/1.2.563.0/0.8.045
Coagulation5.3/6.0.470/0.5.541.4/0.1.0020/1.7.260/00/1.7.781.5/0.5.25
Gastrointestinal*4.0/5.8.566.7/4.0.4816.2/3.6<.00116.4/7.0.00720.3/4.2<.00117.9/7.7.1315.2/6.7.027
Hepatic10.7/7.2.5216.0/10.8.1716.2/12.9.389.6/4.8.07810.1/11.7.923.6/6.0.8425.8/31.2.14
Infection/febrile neutropenia14.7/15.3.8418.7/9.9.01412.2/8.3.4628.8/23.9.4311.6/8.5.3732.1/26.4.7350.0/42.1.26
Neurology2.7/5.1.606.7/4.2.194.1/3.6.881.4/2.9.732.9/1.9.827.1/3.0.367.6/3.8.18
Renal/genitourinary0/0.5.830/0.4.880/0.1.850/0.2.950/0.1.850/0.2.810/0.3.64
  • —, not calculated.

  • * Differences in incidence mainly due to mucositis.