Table 1.

Interim maintenance regimens

Oral methotrexate regimenIV methotrexate regimen
Vincristine: 1.5 mg/m2 days 0 and 28Vincristine: 1.5 mg/m2 (maximum, 2 mg) every 10 d × 5
Dexamethasone: PO 6 mg/m2/d days 0-4 and days 28-32Methotrexate: initial dose: 100 mg/m2 escalate by 50 mg/m2 per toxicity parameters every 10 d × 5
Methotrexate: PO 20 mg/m2 weekly × 8Methotrexate intrathecal day 30
Mercaptopurine: PO 75 mg/m2/d days 0-49
Methotrexate: intrathecal day 28