Table 2.

Characteristics of randomized patients with and without DS

DSTotal DS, n = 75Non-DS, n = 2003P*
PO MTX, n = 44IV MTX, n = 31P*
Age at diagnosis, y
 <220.332184.07
 2-53220521393
 6-9101121426
Sex
 Female2413.28371110.30
 Male201838893
WBC
 <20 × 109/L3629.18651659.39
 ≥20 × 109/L8210343
 Unknown/missing0001
CNS status
 CNS-13927.64661772.99
 CNS-221399
 CNS-30005
 Unknown/missing336127
Cytogenetics
 ETV6-RUNX110.991357<.001
 Double trisomies 4 and 1051.396244.27
BM day 7
 M12818.6446900.016
 M26713599
 M38614424
 Uninterpretable20235
 Not done/missing00045
BM day 14
 M11813311065.99
 M200031
 M30000
 Uninterpretable0001
 Not done/missing261844905
  • —, not calculated.

  • * The χ2 or Fisher's exact test was used after excluding unknown/missing/uninterpretable/not done groups.

  • Patients (n = 1041) were analyzed for the presence of ETV6-RUNX1 transcript.

  • Patients (n = 1330) were analyzed for the presence of trisomies 4 and 10.