Table 2.

Genetic features of NPM1 MN, NPM1+ MN, and NPM1+ AML cohorts

NPM1 MN (n = 95)NPM1+ MN (n = 45)NPM1+ AML (n = 119)
Comutations, by pathway, n (%)
 DNMT3A14 (15)*15 (33)57 (48)
 IDH122 (2)4 (9)*25 (21)*
 IDH25 (5)2 (4)*16 (13)*
 TET229 (31)7 (16)32 (27)
 ASXL130 (32)*4 (9)3 (3)
 RUNX120 (21)*0 (0)1 (0.8)
 KRAS3 (3)1 (2)4 (3)
 NRAS8 (8)4 (9)27 (23)
 FLT3 (non-ITD)1 (1)3 (7)29 (24)
 FLT3-ITD1 (1)1 (2)36 (30)
 PTPN112 (2)*6 (13)25 (21)
 SRSF220 (21)3 (8)9 (8)
 SF3B19 (9)4 (9)1 (0.8)
 TP5315 (16)*1 (2)0 (0)
Mutation count, median (range)2 (0-8)2 (1-7)4 (1-8)§
Abnormal karyotype, n (%)57 (61)*5 (12)18 (16)
  • * IDH1 and IDH2 are grouped for the analysis comparing NPM1+ MN with NPM1+ AML (Fisher's exact test).

  • KRAS and NRAS are grouped for the analysis comparing NPM1+ MN with NPM1+ AML (Fisher's exact test).

  • Significantly different compared with NPM1+ MN (Fisher's exact test).

  • § P < .05 for difference compared with NPM1+ MN (Mann-Whitney U test).