Table 1.

Echocardiography analyses of the experimental mice

ParameterFibWT AA/B6Fibγ390-396A AA/B6FibWT SSFibγ390-396A SS
IVS;d, mm0.80 ± 0.050.84 ± 0.050.91 ± 0.050.83 ± 0.08
LVPW;d, mm0.80 ± 0.040.81 ± 0.040.84 ± 0.040.77 ± 0.05
LA, mm2.2 ± 0.62.5 ± 0.13.2 ± 0.2*2.8 ± 0.2
MV E, cm/s645 ± 33645 ± 62730 ± 74689 ± 56
MV LW E′, cm/s22 ± 321 ± 231 ± 620 ± 3
MV E/LW E′32 ± 332 ± 431 ± 439 ± 8
Heart rate, bpm344 ± 31330 ± 27372 ± 31383 ± 26
  • Echocardiograms were performed 12 months post-BMT. Similar numbers of fully chimeric male and female mice were used in the experimental groups. Data are presented as mean plus or minus SEM. Statistical significance was determined using 1-way ANOVA followed by the Tukey's multiple comparison test.

  • bpm, beats per minute; LW E′, lateral wall mitral valve tissue Doppler E wave; MV E, mitral valve early filling.

  • * P ≤ .01 vs FibWT AA/B6.

  • P ≤ .05 vs Fibγ390-396A AA/B6.