Table 1.

Comparison of P50 values of HbF cotreated with 2,3-BPG and phthalides vs that of HbA treated solely with 2,3-BPG

EffectorHbAHbFΔP50, mm Hg
0.6 mM 2,3-BPG16.2415.05−1.19
0.6 mM 2,3-BPG + 0.6 mM z-butylidenephthalide16.300.06
4 mM 2,3-BPG18.8316.56−2.27
4 mM 2,3-BPG + 2.5 mM z-butylidenephthalide18.630.20
4 mM 2,3-BPG + 4 mM z-butylidenephthalide19.540.71
4 mM 2,3-BPG + 4 mM z-ligustilide18.740.09
  • ▵P50 = (P50 of HbF cotreated with 2,3-BPG and chosen phthalide) – (P50 of HbA treated solely with 2,3-BPG at the same level).