Table 2.

Adverse events experienced by at least 2 patients on study, ordered by decreasing frequency of occurrence of any grade toxicity

EventAny gradeGrade 3 or 4
ALT increase17 (63)14 (52)
AST increase17 (63)11 (41)
Decreased neutrophil count13 (48)9 (33)
Fever11 (41)0 (0)
Colitis/diarrhea10 (37)4 (15)
Fatigue8 (30)0 (0)
Rash (maculopapular)8 (30)2 (7)
Nausea7 (26)0 (0)
Infusion-related reaction6 (22)1 (4)
Myalgia5 (19)1 (4)
Abdominal pain4 (15)0 (0)
Chills4 (15)0 (0)
Anemia3 (11)1 (4)
Constipation3 (11)0 (0)
Cough3 (11)0 (0)
Dysgeusia3 (11)0 (0)
Limb edema3 (11)0 (0)
Other infections and infestations3 (11)2 (7)
Pneumonitis3 (11)2 (7)
Vomiting3 (11)0 (0)
Increased alkaline phosphatase2 (7)1 (4)
Anorexia2 (7)0 (0)
Increased bilirubin2 (7)0 (0)
Bronchial infection2 (7)0 (0)
Dyspnea2 (7)0 (0)
Gastroesophageal reflux disease2 (7)0 (0)
Hyponatremia2 (7)2 (7)
Lung infection2 (7)2 (7)
Malaise2 (7)0 (0)
Acneiform rash2 (7)0 (0)
Weight loss2 (7)1 (4)
Decreased white blood cell count2 (7)0 (0)
  • Data are n (%).