Table 1.

MIR155HG expression is an IPI-independent prognostic marker for R-CHOP-treated patients with GCB-DLBCL

nno.SimpleMultiple
HR95% CIPHR95% CIP
All DLBCL
 miR-155
  Low293901
  High2931071.170.88-1.54.28
 IPI
  0-171611
  2-3314843.761.64-8.61.00173.421.49-7.84.0038
  4-52011069.614.22-21.887.19e-088.293.62-18.985.73e-07
 Subclass
  ABC24210511
  GCB248580.450.33-0.621.09e-060.550.40-0.76.00032
  UC96340.730.50-1.08.110.710.48-1.05.089
ABC-DLBCL
 miR-155
  Low121571
  High121480.780.53-1.14.20
 IPI
  0-11521
  2-3125383.570.86-14.89.080
  4-51026510.372.51-42.87.0012
GCB-DLBCL
 miR-155
  Low1244111
  High124170.400.23-0.71.00170.460.26-0.81.0071
 IPI
  0-148211
  2-3140326.221.49-25.97.0125.911.42-24.69.015
  4-5602412.532.96-53.06.000611.102.61-47.15.0011
  • Array-based miR-155 expression and outcome were analyzed by simple and multiple Cox proportional hazards regression analyses for OS. IPI (international prognostic index) score information was not available for all patients, thus cohort sizes are reduced in this setting (115 samples were removed). MIR155HG expression was dichotomized by median split in each of the individual cohorts: all DLBCL patients, ABC-classified patients, and GCB-classified patients.

  • —, value not available because variables were only included in multiple Cox proportional hazards regression analysis if significant results were obtained in simple Cox proportional hazards regression analysis; CI, 95% lower and upper confidence intervals; HR, hazard ratio; n, number of samples; no., number of events.