Table 2.

RV and BTZ combination therapy CI values

Cell lineDose 1: ED50/8Dose 2: ED50/4Dose 3: ED50/2Dose 4: ED50Dose 5: 2 × ED50
RPMI82263.31 ± 1.692.01 ± 0.672.30 ± 0.550.70 ± 0.010.43 ± 0.01
KMS110.16 ± 0.700.05 ± 0.010.06 ± 0.010.10 ± 0.010.17 ± 0.03
OPM20.12 ± 0.010.20 ± 0.020.29 ± 0.020.38 ± 0.040.30 ± 0.02
  • CI values for RV and BTZ were generated using Calcusyn software. Synergism was determined per Chou-Talalay method; bold type indicates CI <1, denoting a synergistic response, CI >1 denotes an antagonistic response, and CI = 1 denotes an additive response.