Table 2.

Univariable logistic regression models of pregnancy complication risk (n = 40 pregnancies)

VariableOR95% CI
Demographic and clinical variables
Mean age (per 5-y increase)0.410.19-0.87
Prior history of thrombosis0.600.10-3.50
Prior history of pregnancy complications*1.550.39-6.14
Autoimmune rheumatic disease0.550.12-2.5
LDA aloneN/EN/E
LMWH (any dose level) aloneN/EN/E
Laboratory variables
Rosner index (per doubling)4.511.08-18.93
aPTT-LA (per doubling)5.210.80-33.87
aCL IgM (per doubling)0.930.55-1.57
aCL IgG (per doubling)1.420.90-2.23
aß2GPI IgM (per doubling)§0.740.49-1.12
aß2GPI IgG (per doubling) §1.080.74-1.57
Triple antibody positivity§2.700.63-11.68
  • CIs were adjusted for the dependent data structure (ie, that women could have >1 pregnancy).

  • N/E, not evaluated.

  • * Pregnancy complications were defined according to revised Sapporo criteria.1

  • Autoimmune rheumatic disease was defined as 4 cases of systemic lupus erythematosus and 1 case of lupus-like disease.

  • Laboratory variables were log2-transformed to stabilize skewed distributions. Corresponding ORs represent the relative increase in the odds of a pregnancy complication per doubling of the respective laboratory parameter.

  • § aß2GPI IgG/IgM antibodies missing in 1 pregnancy. Cutoffs for triple antibody positivity were defined as follows: aCL >40 GPL/MPL U/mL, aβ2GPI IgG >8 GPL/MPL U/mL.