Table 1.

Cox regression models comparing the risk of an event between different genetic ungroups defined by the UKALL-CNA and revised genetic classifiers

ClassifierOverallMRD adaptedNon–MRD adapted
Hazard ratio95% CIPHazard ratio95% CIPHazard ratio95% CIP
Univariate models
 UKALL-CNA
  CNA-GR vs CNA-IR0.480.40-0.57<.0010.510.39-0.66<.0010.450.35-0.58<.001
  CNA-PR vs CNA-IR1.431.12-1.82.0041.390.96-2.01.081.421.03-1.96.03
 Genetic risk
  GEN-GR vs GEN-VGR1.681.29-2.19<.0011.330.93-1.91.122.191.46-3.29<.001
  GEN-IR vs GEN-GR2.051.65-2.53<.0012.031.46-2.82<.0012.031.53-2.69<.001
  GEN-PR vs GEN-IR1.951.51-2.53<.0011.831.23-2.72.0032.131.51-3.01<.001
Models stratified by treatment risk group
 UKALL-CNA
  CNA-GR vs CNA-IR0.530.44-0.64<.0010.530.41-0.70<.0010.520.41-0.67<.001
  CNA-PR vs CNA-IR1.311.02-1.66.031.270.87-1.84.221.330.97-1.83.08
 Genetic risk
  GEN-GR vs GEN-VGR1.621.24-2.12<.0011.300.90-1.89.162.061.37-3.09.001
  GEN-IR vs GEN-GR1.861.50-2.31<.0011.891.36-2.65<.0011.821.37-2.42<.001
  GEN-PR vs GEN-IR1.361.02-1.81.041.460.94-2.26.091.360.94-1.99.11
  • CI, confidence interval; VGR, very good risk.