Table 2.

Patient outcomes

Arm A: decitabine (n = 82)Arm B: decitabine + bortezomib (n = 81)P (2 sided)
n (%; 95% CI) achieving CR + CRi rate32 (39; 28-50)31 (38; 28-50).91*
Median (range) time to response, mo3.6 (0.9-17.2)2.3 (1.7-7.9).32
Median (95% CI) duration of response, CR + CRi, mo10.9 (5.7-19.6)15.3 (10.4-NA).15§
Median (95% CI) OS, mo9.3 (5.8-12.2)8.9 (3.8-14.3).18
Median (95% CI) OS after transplantation, moNA (n = 9)31.1 (4.6-NA).98§
  • NA, not attained.

  • * Mantel-Haenszel test.

  • Two-sided rank sum test.

  • Kaplan-Meier estimate.

  • § Two-sided stratified log-rank test.

  • One-sided stratified log-rank test.

  • Landmark Kaplan-Meier estimate from time of transplantation to death resulting from any cause.