Table 2.

Observed somatic mutations in MYD88WT WM

GeneConsequenceChrPositionVariantProteinCOSMICCADD
BCL10Nonsense185733609T/Ap.135R>*COSM22063838
BCL10Frameshift185733357-8−/AGAGTTTGCACAAGp.-/218-219LVQTXNA
CXCR4Deletion2136872441-82TCTGTTTCCACTGAGTC TGAGTCTTCAAGTTTT CACTCCAGCTaa/taap.SVSTESESSSFH SS*339-353*NA
CXCR4Frameshift2136872566-7−/Tp.T315NXNA
CXCR4Missense2136873098G/Tp.R134S26.9
NFKBIZMissense3101574709A/Cp.K45T26.3
TBL1XR1Missense3176743302A/Gp.510L>S26.1
TBL1XR1Missense3176744171G/Ap.S503LCOSM500034334
TBL1XR1Splice acceptor3176750925C/GNA25.8
TBL1XR1Deletion3176756175-7AAG/−p.SC324-325CCOSM3205534NA
TBL1XR1Nonsense3176767829G/Ap.Q220*39
TBL1XR1Missense3176768267C/Gp.G187GR33
TBL1XR1Frameshift3176769342T/−p.N126NXCOSM142070634
PTPN13Missense487556423T/Ap.L5Q33
PTPN13Missense487656789G/Tp.A732SCOSM501985927.6
PTPN13Missense487683919A/Cp.N1198T3.649
PTPN13Missense487696460C/Ap.P1882QCOSM48165025.4
NFKB1Missense4103459060G/Ap.G69R31
KMT2CNonsense7151891205C/Ap.G1517*COSM330422441
NOTCH1Nonsense9139390945G/Ap.Q2416*COSM477510841
NFKB2Deletion10104160996-1855NANANA
NFKB2Deletion10104160849-1688NANANA
ATMNonsense11108175504C/Tp.Q1867*37
ATMMissense11108204685T/Cp.M2667T26.3
KMT2DFrameshift1249433373-4−/G CCG CCCCCCTp.-2691-NA
2692AAPX
KMT2DMissense1249445543T/Gp.E641D5.499
KMT2DMissense1249446710G/Tp.P367Q11.92
KMT2DFrameshift1249448408G/−p.G101X'NA
TP53Missense177577108C/Ap.C277FCOSM56233834
TP53Missense177577114C/Ap.C275FCOSM9993234
MALT1Nonsense1856414859C/Tp.Q743*36
MALT1Nonsense1856414882C/Ap.Y750*36
NFKBIBFrameshift1939398226-7CT/−p.P299XCOSM5081722NA
UFD1LMissense2219443248C/Ap.G145V23.6
KDM6AMissenseX44911044T/Ap.L249I25.4
KDM6AFrameshiftX44942757G/−p.V1113XCOSM5031082NA
KDM6AFrameshiftX44922936-7−/GGAAGTGGAAGTp-/.599-NA
AAT GGAAAC GTGCC600GSGSNGNVX
  • CADD, combined annotation dependent depletion; chr, chromosome; COSMIC, Catalogue of Somatic Mutations in Cancer.