Volume 2, Issue 10


Cover Image

Cover Figure: TTLR2 activation induces iron retention in human macrophages. See the article by Abreu et al.

WASHINGTON, May 22,  2018 – Welcome to the “Advance Notice,”  newsletter which provides highlights from issues of Blood Advances, the open-access journal of the American Society of Hematology (ASH), that  are hand-picked by Blood Advances Editor-in-Chief Robert Negrin, MD.

It is well recognized that patients with myelofibrosis can sustain extramedullary hematopoiesis in the spleen and other organs. Qiu and colleagues explore the role and characterization of splenic sinusoid lining cells and reach interesting and provocative finding.

The interplay between psychiatric disorders and other medical conditions can result in significant challenges. The study by Niazi and colleagues explores the impact of psychiatric comorbidities on the treatment of patients with multiple myeloma, demonstrating more health care utilizations and complications in patients with coexisting psychiatric disturbances.

Recent studies have demonstrated that oral factor Xa (FXa) inhibitors are effective in the treatment of patients with atrial fibrillation. However, meta-analyses have reported a higher risk of major bleeding with rivaroxaban than other FXa inhibitors. Yoshioka and colleaguesevaluated the dose of rivaroxaban, with important clinical findings.

Patients with factor XI deficiency have variable bleeding risk. Gidley and colleagues used plasma clot formation, structure, and fibrinolysis assays to detect bleeding. Results from this study may be used to identify those patients who are more or less likely to have bleeding clinically.


Natural killer (NK) cells are known to play an important role in the immunosurveillance of chronic viral infections and malignancies.Forconi and colleagues analyzed the infiltration of NK cells in children with Burkitt lymphoma, with interesting findings.

Featured Visual Abstract

Role of the hepcidin-ferroportin axis in pathogen-mediated intracellular iron sequestration in human phagocytic cells

Iron is an essential trace metal for all living organisms. During infection, there is competition for iron stores required by both the host and pathogen. Abreu and colleagues explore the role of Toll-like receptor signaling on iron sequestration in macrophages, highlighting the role of this cell population during infection.




Blood Advances is the open-access journal of the American Society of Hematology (ASH) (, the world’s largest professional society concerned with the causes and treatment of blood disorders.

ASH’s mission is to further the understanding, diagnosis, treatment, and prevention of disorders affecting blood, bone marrow, and the immunologic, hemostatic, and vascular systems by promoting research, clinical care, education, training, and advocacy in hematology.